Challenges and prospects for monoclonal antibodies in China

Authors

  • Honghao Shi
  • Meiwan Chen
  • Yunzhen Shi
  • Hao Hu University of Macau
  • Yitao Wang

DOI:

https://doi.org/10.5912/jcb594

Keywords:

Biotechnology, China, humanized product, monoclonal antibody

Abstract

The technology of monoclonal antibodies has been developed since the 1990s and is attracting more and more attention in China during the 21st century. The first monoclonal antibody product was introduced by the Chinese local producer in 1999, and presently seven products are listed, of which three are humanized products. There are several technical constraints that are affecting the development of monoclonal antibodies in China: limitations to the number of drug targets, restricted biological diffusion, limitations to administration routes, and species-specific issues, as well as China’s own limitations in production and R&D capabilities. This article provides suggestions relevant for the Chinese development of monoclonal antibodies. In the long run China is expected to catch up with its own technology roadmap.

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Published

2013-04-01

Issue

Section

Articles